Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data.

@article{Lombardino1975AcidicAA,
  title={Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data.},
  author={Joseph G. Lombardino and Ivan G. Otterness and Edward H. Wiseman},
  journal={Arzneimittel-Forschung},
  year={1975},
  volume={25 10},
  pages={1629-35}
}
Fifteen acidic antiinflammatory agents, for which some clinical data have previously been published, have been examined for their potency in the carrageenan-induced rat foot edema test, and for their acidity (pKa) and partition coefficients. Published serum half-life data and daily clinical (anti-arthritic) dose have been tabulated for these drugs and correlations between these various parameters are discussed. The rat foot edema carrageenan test has proved to be a fairly reliable predictor of… CONTINUE READING