Acidic and uncharged polar residues in the consensus motifs of the yeast Ca2+ transporter Gdt1p are required for calcium transport

@article{Colinet2017AcidicAU,
  title={Acidic and uncharged polar residues in the consensus motifs of the yeast Ca2+ transporter Gdt1p are required for calcium transport},
  author={Anne-Sophie Colinet and Louise Thines and Antoine Deschamps and Ga{\"e}lle Fl{\'e}mal and Didier Demaegd and Pierre Morsomme},
  journal={Cellular Microbiology},
  year={2017},
  volume={19},
  pages={&NA;}
}
The UPF0016 family is a recently identified group of poorly characterized membrane proteins whose function is conserved through evolution and that are defined by the presence of 1 or 2 copies of the E-φ-G-D-[KR]-[TS] consensus motif in their transmembrane domain. We showed that 2 members of this family, the human TMEM165 and the budding yeast Gdt1p, are functionally related and are likely to form a new group of Ca2+ transporters. Mutations in TMEM165 have been demonstrated to cause a new type… CONTINUE READING

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