Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice.

@article{Montao2008AcidicAA,
  title={Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice.},
  author={Adriana Maria Monta{\~n}o and Hirotaka Oikawa and Shunji Tomatsu and Tatsuo Nishioka and Carole Vogler and M{\'o}nica A Guti{\'e}rrez and Toshihiro Oguma and Yun Rui Eileen Tan and Jeffrey H. Grubb and Vũ Ch{\'i} Dũng and Amiko Ohashi and Ken-Ichi Miyamoto and Tadao Orii and Yukio Yoneda and William S. Sly},
  journal={Molecular genetics and metabolism},
  year={2008},
  volume={94 2},
  pages={178-89}
}
We have tested an acidic oligopeptide-based targeting system for delivery of enzymes to tissues, especially bone and brain, in a murine mucopolysaccharidosis type VII (MPS VII) model. This strategy is based upon tagging a short peptide consisting of acidic amino acids (AAA) to N terminus of human beta-glucuronidase (GUS). The pharmacokinetics… CONTINUE READING