Acidic Dissociation of 7 : 9-Dialkylguanines and its Possible Relation to Mutagenic Properties of Alkylating Agents

@article{Lawley1961AcidicDO,
  title={Acidic Dissociation of 7 : 9-Dialkylguanines and its Possible Relation to Mutagenic Properties of Alkylating Agents},
  author={Philip D. Lawley and Peter Brookes},
  journal={Nature},
  year={1961},
  volume={192},
  pages={1081-1082}
}
Watson and Crick1 proposed as a possible mechanism for mutation that changes in the tautomeric structure of a base of deoxyribonucleic acid (DNA) could induce its pairing with an anomalous base. In considering the possible correlation between the action of alkylating agents on DNA and the mutagenic activity of these agents, we mentioned in a recent report2 that it was not obvious how the initial action of alkylation of DNA, which has been shown to occur at N(7) of guanine moieties3,4, could… CONTINUE READING

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