Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease

@inproceedings{Lee2014AcidSM,
  title={Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease},
  author={Jong Kil Lee and Hee Kyung Jin and Min Hee Park and Bo-Ra Kim and Phil Hyu Lee and Hiromitsu Nakauchi and Janet Carter and Xingxuan He and Edward H Schuchman and Jae-Sung Bae},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
In Alzheimer's disease (AD), abnormal sphingolipid metabolism has been reported, although the pathogenic consequences of these changes have not been fully characterized. We show that acid sphingomyelinase (ASM) is increased in fibroblasts, brain, and/or plasma from patients with AD and in AD mice, leading to defective autophagic degradation due to lysosomal depletion. Partial genetic inhibition of ASM (ASM(+/-)) in a mouse model of familial AD (FAD; amyloid precursor protein [APP]/presenilin 1… CONTINUE READING
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