Acid sphingomyelinase is required for lipid Raft TLR4 complex formation.

@article{Cuschieri2007AcidSI,
  title={Acid sphingomyelinase is required for lipid Raft TLR4 complex formation.},
  author={Joseph Cuschieri and Eileen M. Bulger and Jens Billgrin and Iris A. Garc{\'i}a and Ronald V. Maier},
  journal={Surgical infections},
  year={2007},
  volume={8 1},
  pages={91-106}
}
BACKGROUND Lipid rafts, composed of sphingolipids, are critical to Toll-like receptor 4 (TLR4) assembly during lipopolysaccharide (LPS) exposure as a result of phosphokinase C (PKC)-zeta activation. However, the mechanism responsible for these events remains unknown. PURPOSE We determined whether LPS-induced TLR4 assembly and activation are dependent on the sphingolipid metabolite ceramide, produced by acid sphingomyelinase following the initial binding of LPS to CD14. METHODS Cultured THP… CONTINUE READING