Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis

Abstract

Pulmonary edema associated with increased vascular permeability is a severe complication of Staphylococcus aureus–induced sepsis and an important cause of human pathology and death. We investigated the role of the mammalian acid sphingomyelinase (Asm)/ceramide system in the development of lung edema caused by S. aureus. Our findings demonstrate that genetic… (More)
DOI: 10.1007/s00109-014-1246-y

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Cite this paper

@inproceedings{Peng2014AcidSI, title={Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis}, author={Huiming Peng and Cao Li and Stephanie Kadow and Brian D. Henry and Joerg Steinmann and K. A. Becker and Andrea Riehle and Natalie Beckmann and Barbara Wilker and Pin Li and Timothy A. Pritts and Michael J. Edwards and Yang Zhang and Erich Gulbins and Heike Grassm{\'e}}, booktitle={Journal of Molecular Medicine}, year={2014} }