Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways.

@article{GarciaRuiz2015AcidSS,
  title={Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways.},
  author={Carmen Garcia-Ruiz and Jose M. Mato and Dennis E. Vance and Neil Kaplowitz and Jos{\'e} C Fern{\'a}ndez-Checa},
  journal={Journal of hepatology},
  year={2015},
  volume={62 1},
  pages={219-33}
}
Steatohepatitis (SH) is an intermediate stage of fatty liver disease and is one of the most common causes of chronic liver disease worldwide that may progress to cirrhosis and liver cancer. SH encompasses alcoholic and non-alcoholic steatohepatitis, the latter being of particular concern as it is associated with obesity and insulin resistance and has become a major cause of liver transplantation. The molecular mechanisms governing the transition from steatosis to SH are not fully understood… CONTINUE READING