Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts.

@article{Eshcol2008AcidsensingIC,
  title={Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts.},
  author={Jayasheel O. Eshcol and Anne Marie S. Harding and Tomonori Hattori and V{\'i}vian Flores Costa and Michael J. Welsh and Christopher J. Benson},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={295 3},
  pages={
          C732-9
        }
}
Acid-sensing ion channel 3 (ASIC3) is a H(+)-gated cation channel primarily found in sensory neurons, where it may function as a pH sensor in response to metabolic disturbances or painful conditions. We previously found that ASIC3 interacts with the postsynaptic density protein PSD-95 through its COOH terminus, which leads to a decrease in ASIC3 cell surface expression and H(+)-gated current. PSD-95 has been implicated in recruiting proteins to lipid rafts, which are membrane microdomains rich… CONTINUE READING

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The neural cell adhesion molecule regulates cell-surface C738 PSD-95 MODULATES ASIC3 IN LIPID RAFTS AJP-Cell Physiol

  • M Delling, E Wischmeyer, +4 authors M. Schachner
  • Jne 23,
  • 2008
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