Acid-sensing ion channel-1b in the stereocilia of mammalian cochlear hair cells

@article{Ugawa2006AcidsensingIC,
  title={Acid-sensing ion channel-1b in the stereocilia of mammalian cochlear hair cells},
  author={Shinya Ugawa and Akira Inagaki and Hisao Yamamura and Takashi Ueda and Yusuke Ishida and Kenji Kajita and Hideo Shimizu and Shoichi Shimada},
  journal={NeuroReport},
  year={2006},
  volume={17},
  pages={1235-1239}
}
  • Shinya Ugawa, Akira Inagaki, +5 authors Shoichi Shimada
  • Published in Neuroreport 2006
  • Biology, Medicine
  • NeuroReport
  • We investigated whether amiloride-blockable proton-gated cation channels ASIC1a (acid-sensing ion channel-1a) and ASIC1b are expressed in the stereocilia of mouse cochlear hair cells. In-situ hybridization studies showed that ASIC1b transcripts, but not ASIC1a transcripts, were expressed in the inner and outer hair cells. Fluorescent immunohistochemical and immunogold electron microscopic analyses revealed that the ASIC1b channels were located at the insertions of the stereocilia into the hair… CONTINUE READING

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