Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.

@article{Wemmie2003AcidsensingIC,
  title={Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.},
  author={John A. Wemmie and Candice C. Askwith and Ejvis Lamani and Martin D. Cassell and John H. Freeman and Michael J. Welsh},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 13},
  pages={5496-502}
}
The acid-sensing ion channel, ASIC1, contributes to synaptic plasticity in the hippocampus and to hippocampus-dependent spatial memory. To explore the role of ASIC1 in brain, we examined the distribution of ASIC1 protein. Surprisingly, although ASIC1 was present in the hippocampal circuit, it was much more abundant in several areas outside the hippocampus. ASIC1 was enriched in areas with strong excitatory synaptic input such as the glomerulus of the olfactory bulb, whisker barrel cortex… CONTINUE READING
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