Acid secretory and duodenal ulcerogenic responses induced by mepirizole in anesthetized rats

Abstract

The role of body temperature in the acid stimulatory mechanism by meprizole, a duodenal ulcerogen, was investigated in urethane-anesthetized rats. Subcutaneous administration of mepirizole (60 and 200 mg/kg) increased acid secretion in a dose-dependent manner and resulted in duodenal lesions within 8 hr. The acid secretory and ulcerogenic responses induced… (More)
DOI: 10.1007/BF02087767

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