Acid secretion during indomethacin therapy. Effect of misoprostol.

  title={Acid secretion during indomethacin therapy. Effect of misoprostol.},
  author={S. D. Taylor and W. Chey and J. Scheiman},
  journal={Journal of clinical gastroenterology},
  volume={20 2},
Secretin is an important physiologic regulator of gastric acid and pancreatic bicarbonate secretion. Endogenous prostaglandins play an important intermediary role, because indomethacin pretreatment prevents the physiological actions of secretin. Misoprostol is a prostaglandin E1 (PGE1) analog used for the prevention of nonsteroidal antiinflammatory drug (NSAID)-induced ulceration. This study sought to determine whether cotherapy with misoprostol reverses the NSAID-induced blockade of secretin's… Expand
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