Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascade.

@article{Vliet2004AcidresponsiveGI,
  title={Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascade.},
  author={Arnoud H M van Vliet and Ernst J Kuipers and Jeroen Stoof and Sophie W Poppelaars and Johannes G Kusters},
  journal={Infection and immunity},
  year={2004},
  volume={72 2},
  pages={766-73}
}
Although the adaptive mechanisms allowing the gastric pathogen Helicobacter pylori to survive acid shocks have been well documented, the mechanisms allowing growth at mildly acidic conditions (pH approximately 5.5) are still poorly understood. Here we demonstrate that H. pylori strain 26695 increases the transcription and activity of its urease, amidase, and formamidase enzymes four- to ninefold in response to growth at pH 5.5. Supplementation of growth medium with NiCl2 resulted in a similar… CONTINUE READING

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A.H.M. van Vliet, J. Stoof, +5 authors J. G. Kusters
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