• Medicine, Chemistry
  • Published in Clinical chemistry 1977

Acid phosphatase isoenzymes in Gaucher's disease.

  title={Acid phosphatase isoenzymes in Gaucher's disease.},
  author={David W. Mercer and Stephen P. Peters and Robert H. Glew and Robin E B Lee and D M Wenger},
  journal={Clinical chemistry},
  volume={23 4},
Acid phosphatase (EC isoenzyme profiles of extracts of splenic tissue and serum from patients with Gaucher's disease were measured by a mini-column ion-exchange chromatographic method [Clin. Chem., 23, 000 (1977)]. Diagnosis of Gaucher's disease in the five patients studied was confirmed by demonstrating decreased (2.3 to 4.1% of normal) glucocerebrosidase activity in the spleen. With p-nitrophenyl phosphate as substrate, increased acid phosphatase activity (three-to eight-fold normal… CONTINUE READING