Acid pH-activated glycol chitosan/fullerene nanogels for efficient tumor therapy.

  title={Acid pH-activated glycol chitosan/fullerene nanogels for efficient tumor therapy.},
  author={Sol Kim and Dong Jin Lee and Dong Sup Kwag and Ung Yeol Lee and Yu Seok Youn and Eun Seong Lee},
  journal={Carbohydrate polymers},
Glycol chitosan (GC) grafted with 2,3-dimethylmaleic acid (DMA) and fullerene (C60) conjugates (GC-g-DMA-g-C60) were developed for use in a photosensitizer prodrug. GC-g-DMA-g-C60 was prepared via the simple two-step chemical grafting reactions of (i) DMA to free amine groups of GC and (ii) hydroxyl groups of GC-g-DMA to ππ carbon bonds of C60. This conjugate was self-assembled to form polysaccharidic nanogels consisting of a hydrophilic block (GC and DMA) and a hydrophobic block (C60). Here… CONTINUE READING
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