Acid-mediated tumor invasion: a multidisciplinary study.


The acid-mediated tumor invasion hypothesis proposes altered glucose metabolism and increased glucose uptake, observed in the vast majority of clinical cancers by fluorodeoxyglucose-positron emission tomography, are critical for development of the invasive phenotype. In this model, increased acid production due to altered glucose metabolism serves as a key… (More)


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@article{Gatenby2006AcidmediatedTI, title={Acid-mediated tumor invasion: a multidisciplinary study.}, author={Robert A. Gatenby and Edward T. Gawlinski and Arthur F. Gmitro and Brant M. Kaylor and Robert J. Gillies}, journal={Cancer research}, year={2006}, volume={66 10}, pages={5216-23} }