Acid lipase cross-reacting material in Wolman disease and cholesterol ester storage disease.

@article{Burton1981AcidLC,
  title={Acid lipase cross-reacting material in Wolman disease and cholesterol ester storage disease.},
  author={Barbara K. Burton and Steve Reed},
  journal={American journal of human genetics},
  year={1981},
  volume={33 2},
  pages={203-8}
}
Material cross-reacting with antibodies to acid lipase was demonstrated in fibroblasts of three patients with Wolman disease and three with cholesterol ester storage disease. Quantitation of the immunologically cross-reacting material (CRM) by a single radial immunodiffusion method revealed normal levels in both mutant cell types. CRM specific activity toward triolein and cholesteryl oleate was reduced about 200-fold in the Wolman disease fibroblasts and 50- to 100-fold in the cholesterol ester… CONTINUE READING