Acid-labile subunit (ALS) deficiency.

  title={Acid-labile subunit (ALS) deficiency.},
  author={Horacio M Domen{\'e} and Vivian Hwa and H{\'e}ctor Guillermo Jasper and Ron G. Rosenfeld},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  volume={25 1},
The acid-labile subunit (ALS) protein is crucial for maintaining the integrity of the circulating IGF/IGFBP system. In humans, complete ALS deficiency is characterized by severely reduced serum IGF-I and IGFBP-3 concentrations that is incongruent with the associated mild growth retardation (height SDS -2 to -3 SDS before and during puberty). Twenty-one patients have been described with ALS deficiency, representing 16 unique homozygous or compound heterozygous inactivating mutations of the… CONTINUE READING
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