Acid-induced modulation of airway basal tone and contractility: role of acid-sensing ion channels (ASICs) and TRPV1 receptor.

@article{Faisy2007AcidinducedMO,
  title={Acid-induced modulation of airway basal tone and contractility: role of acid-sensing ion channels (ASICs) and TRPV1 receptor.},
  author={Christophe Faisy and Benjamin Planquette and Emmanuel Naline and Paul-Andr{\'e} Risse and Nelly Frossard and J. -Y. Fagon and Charles Advenier and P Devillier},
  journal={Life sciences},
  year={2007},
  volume={81 13},
  pages={1094-102}
}
The role of extracellular acidosis in inflammatory airway diseases is not well known. One consequence of tissue acidification is the stimulation of sensory nerves via the polymodal H(+)-gated transmembrane channels ASICs and TRPV1 receptor. The present study investigated the effect of acidosis on airway basal tone and responsiveness in the guinea pig. Acidosis (pH 6.8, 10 min, 37 degrees C) significantly decreased the basal tone of tracheal rings (p<0.01 vs. paired control). Moreover, pH fall… CONTINUE READING

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