Acid-induced conformational modification of the hemagglutinin molecule alters interaction of influenza virus with antigen-presenting cells.

@article{Eisenlohr1988AcidinducedCM,
  title={Acid-induced conformational modification of the hemagglutinin molecule alters interaction of influenza virus with antigen-presenting cells.},
  author={Laurence Eisenlohr and Walter Gerhard and Charles J. Hackett},
  journal={Journal of immunology},
  year={1988},
  volume={141 6},
  pages={1870-6}
}
Brief exposure of influenza virus to pH 5 was found to have extensive effects upon presentation of viral Th cell antigenic determinants. This acidity, comparable to that encountered in host cell endosomes, was known to effect conformational changes in the viral hemagglutinin (HA) which alter the molecule's fusion activity, antigenicity, and susceptibility to enzymes. Three major effects of low pH upon presentation of viral T cell determinants were observed: first, acid pretreatment permitted… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…