Acid fibroblast growth factor and peripheral nerve grafts regulate Th2 cytokine expression, macrophage activation, polyamine synthesis, and neurotrophin expression in transected rat spinal cords.

@article{Kuo2011AcidFG,
  title={Acid fibroblast growth factor and peripheral nerve grafts regulate Th2 cytokine expression, macrophage activation, polyamine synthesis, and neurotrophin expression in transected rat spinal cords.},
  author={Huai-Sheng Kuo and Ming-Tzu Tsai and Michael C.-Y. Huang and Chuan-Wen Chiu and Ching-Yi Daphne Tsai and Meng-Jen Lee and W N Huang and Yi-lo Lin and Wen-Chun Kuo and Henrich Cheng},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 11},
  pages={
          4137-47
        }
}
Spinal cord injury elicits an inflammatory response that recruits macrophages to the injured spinal cord. Quantitative real-time PCR results have shown that a repair strategy combining peripheral nerve grafts with acidic fibroblast growth factor (aFGF) induced higher interleukin-4 (IL-4), IL-10, and IL-13 levels in the graft areas of rat spinal cords compared with transected spinal cords at 10 and 14 d. This led to higher arginase I-positive alternatively activated macrophage (M2 macrophage… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 71 REFERENCES

mechanisms facilitate bridging axonal regeneration one year after spinal cord injury

  • KA Kigerl, JC Gensel, DP Ankeny, JK Alexander, DJ Donnelly, PG Popovich
  • 2009
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…