Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential.

@article{Kong2014AcidbaseTI,
  title={Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential.},
  author={Su Kong and Andrea Giannuzzo and Ivana Novak and Stine Falsig Pedersen},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2014},
  volume={92 6},
  pages={449-59}
}
Solid tumors are characterized by a microenvironment that is highly acidic, while intracellular pH (pHi) is normal or even elevated. This is the result of elevated metabolic rates in the highly proliferative cancer cells, in conjunction with often greatly increased rates of net cellular acid extrusion. Studies in various cancers have suggested that while the acid extrusion mechanisms employed are generally the same as those in healthy cells, the specific transporters upregulated vary with the… CONTINUE READING
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