Acid- and salt-triggered multifunctional poly(propylene imine) dendrimer as a prospective drug delivery system.

@article{Paleos2004AcidAS,
  title={Acid- and salt-triggered multifunctional poly(propylene imine) dendrimer as a prospective drug delivery system.},
  author={Constantinos M. Paleos and Dimitris Tsiourvas and Zili Sideratou and Leto A Tziveleka},
  journal={Biomacromolecules},
  year={2004},
  volume={5 2},
  pages={524-9}
}
A novel dendrimeric compound is designed with the objective of simultaneously addressing issues commonly encountered in drug delivery, i.e., stability in biological milieu as well as targeting. For this purpose, a multifunctional dendrimeric system derived from diaminobutane poly(propylene imine) dendrimers (DAB) is prepared bearing at its external surface poly(ethylene glycol) chains and guanidinium moieties. For these moieties, it has been established that they exhibit protective and… CONTINUE READING

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