Acid and particulate-induced aspiration lung injury in mice: importance of MCP-1.

@article{Raghavendran2005AcidAP,
  title={Acid and particulate-induced aspiration lung injury in mice: importance of MCP-1.},
  author={Krishnan Raghavendran and Bruce A Davidson and Barbara A. Mullan and Alan D. Hutson and Thomas A. Russo and Patricia A Manderscheid and James A Woytash and Bruce A. Holm and Robert H. Notter and Paul Knight},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={289 1},
  pages={L134-43}
}
A model of aspiration lung injury was developed in WT C57BL/6 mice to exploit genetically modified animals on this background, i.e., MCP-1(-/-) mice. Mice were given intratracheal hydrochloric acid (ACID, pH 1.25), small nonacidified gastric particles (SNAP), or combined acid plus small gastric particles (CASP). As reported previously in rats, lung injury… CONTINUE READING