• Corpus ID: 37618938

Acid CleavageLDeprotection in Fmoc / tBu Solid-Phase Peptide Synthesis

  title={Acid CleavageLDeprotection in Fmoc / tBu Solid-Phase Peptide Synthesis},
  author={Fritz Dick},
In general, a solid-phase peptide synthesis (SPPS) consists of the assembly of a protected peptide chain on a polymeric support (=synthetic step) and the subsequent cleavage/deprotection to release the crude, deprotected peptide from the solid support (=cleavage step). Usually, these two steps are followed by chromatographic purification of the crude peptide (see Chapters 1,2,4, and 5, PAP). The techniques to synthesize protected peptides or peptide fragments are discussed in Chapter 14. This… 

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