Acid–base regulation of bone metabolism

@inproceedings{Arnett2007AcidbaseRO,
  title={Acid–base regulation of bone metabolism},
  author={Timothy R. Arnett},
  year={2007}
}
It has been known for almost a century that systemic acidosis causes depletion of the skeleton—an effect assumed to result from physicochemical dissolution of bone mineral. However, our work has shown that resorption pit formation by cultured osteoclasts is dependent on extracellular acidification. Osteoclasts are almost inactive above pH 7.4 and show maximum acid- activation at about pH 6.9. Within this pH range, small shifts in H + concentration can cause large changes in resorption. Bone… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Potassium and health.

  • Advances in nutrition
  • 2013
VIEW 3 EXCERPTS
CITES BACKGROUND

On the evolution of arterial vascular patterns of tetrapods.

  • Journal of morphology
  • 2011
VIEW 3 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 77 REFERENCES

Capsaicin is a potent activator of human osteoclasts, Calcif

A. Brandao-Burch
  • Tissue Int
  • 2006
VIEW 1 EXCERPT

Capsaicin is a potent activator of human osteoclasts

A. Brandao-Burch
  • Calcif . Tissue Int .
  • 2005