Achieving specific RNA cleavage activity by an inactive splicing endonuclease subunit through engineered oligomerization.


Protein-protein interaction is a common strategy exploited by enzymes to control substrate specificity and catalytic activities. RNA endonucleases, which are involved in many RNA processing and regulation processes, are prime examples of this. How the activities of RNA endonucleases are tightly controlled such that they act on specific RNA is of general… (More)


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