Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx.

@article{Muppidi2011AchievingCP,
  title={Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx.},
  author={Avinash Muppidi and Zhiyong Wang and Xiaolong Li and Jiandong Chen and Qing Lin},
  journal={Chemical communications},
  year={2011},
  volume={47 33},
  pages={9396-8}
}
We report the design of bisarylmethylene bromides as a new class of rigid, distance-matching cysteine cross-linkers. By cross-linking a peptide dual inhibitor of Mdm2/Mdmx containing cysteines at i,i+7 positions, dramatic enhancement in cell permeability was achieved, along with increased helicity and biological activity. 

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