Achieving Precision Death with Cell-Cycle Inhibitors that Target DNA Replication and Repair.

@article{Lin2017AchievingPD,
  title={Achieving Precision Death with Cell-Cycle Inhibitors that Target DNA Replication and Repair.},
  author={Aimee Bence Lin and Samuel C. McNeely and Richard P. Beckmann},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2017},
  volume={23 13},
  pages={
          3232-3240
        }
}
All cancers are characterized by defects in the systems that ensure strict control of the cell cycle in normal tissues. The consequent excess tissue growth can be countered by drugs that halt cell division, and, indeed, the majority of chemotherapeutics developed during the last century work by disrupting processes essential for the cell cycle, particularly DNA synthesis, DNA replication, and chromatid segregation. In certain contexts, the efficacy of these classes of drugs can be impressive… CONTINUE READING
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