Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo.

@article{Fyodorov2004Acf1CU,
  title={Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo.},
  author={Dmitry V Fyodorov and Michael D Blower and Gary H. Karpen and James T. Kadonaga},
  journal={Genes & development},
  year={2004},
  volume={18 2},
  pages={
          170-83
        }
}
Chromatin assembly is required for the duplication of chromosomes. ACF (ATP-utilizing chromatin assembly and remodeling factor) catalyzes the ATP-dependent assembly of periodic nucleosome arrays in vitro, and consists of Acf1 and the ISWI ATPase. Acf1 and ISWI are also subunits of CHRAC (chromatin accessibility complex), whose biochemical activities are similar to those of ACF. Here we investigate the in vivo function of the Acf1 subunit of ACF/CHRAC in Drosophila. Although most Acf1 null… CONTINUE READING
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