Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.

@article{Siddesha2014AcetylsalicylicAI,
  title={Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.},
  author={Jalahalli M Siddesha and Anthony J Valente and Siva Sankara Vara Prasad Sakamuri and Jason D Gardner and Patrice Delafontaine and Makoto Noda and Bysani Chandrasekar},
  journal={Journal of cellular physiology},
  year={2014},
  volume={229 7},
  pages={845-55}
}
The pathogenesis of cardiac fibrosis and adverse remodeling is thought to involve the ROS-dependent induction of inflammatory cytokines and matrix metalloproteinases (MMPs), and the activation and migration of cardiac fibroblasts (CF). Here we investigated the role of RECK (reversion-inducing-cysteine-rich protein with Kazal motifs), a unique membrane-anchored MMP regulator, on IL-18-induced CF migration, and the effect of acetylsalicylic acid (ASA) on this response. In a Matrigel invasion… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2018

MMP-9 signaling in the left ventricle following myocardial infarction.

American journal of physiology. Heart and circulatory physiology • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…