Acetylsalicylic acid (ASA) increases the solubility of cholesterol when incorporated in lipid membranes.

@article{Alsop2014AcetylsalicylicA,
  title={Acetylsalicylic acid (ASA) increases the solubility of cholesterol when incorporated in lipid membranes.},
  author={Richard J Alsop and Matthew A. Barrett and Songbo Zheng and Hannah Dies and Maikel C. Rheinst{\"a}dter},
  journal={Soft matter},
  year={2014},
  volume={10 24},
  pages={
          4275-86
        }
}
Cholesterol has been well established as a mediator of cell membrane fluidity. By interacting with lipid tails, cholesterol causes the membrane tails to be constrained thereby reducing membrane fluidity, well known as the condensation effect. Acetylsalicylic acid (ASA), the main ingredient in aspirin, has recently been shown to increase fluidity in lipid bilayers by primarily interacting with lipid head groups. We used high-resolution X-ray diffraction to study both ASA and cholesterol… 

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