Acetylsalicylic Acid Prevents Intermittent Hypoxia-Induced Vascular Remodeling in a Murine Model of Sleep Apnea

@inproceedings{SuarezGiron2018AcetylsalicylicAP,
  title={Acetylsalicylic Acid Prevents Intermittent Hypoxia-Induced Vascular Remodeling in a Murine Model of Sleep Apnea},
  author={Monique C. Suarez-Giron and Anabel Lourdes Castro-Grattoni and Marta Ferraz Torres and Ramon Farr{\'e} and Ferran Barb{\'e} and Manuel S{\'a}nchez-de-la-Torre and David Gozal and C{\'e}sar Picado and Josep Mar{\'i}a Montserrat and Isaac Almendros},
  booktitle={Front. Physiol.},
  year={2018}
}
Study objectives: Chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA), induces accelerated atherogenesis as well as aorta vascular remodeling. Although the cyclooxygenase (COX) pathway has been proposed to contribute to the cardiovascular consequences of OSA, the potential benefits of a widely employed COX-inhibitor such (acetylsalicylic acid, ASA) on CIH-induced vascular pathology are unknown. Therefore, we hypothesized that a common non-selective COX… CONTINUE READING
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