Acetylsalicylate (ASA)-induced mitochondrial dysfunction and its potentiation by Ca2+.

  title={Acetylsalicylate (ASA)-induced mitochondrial dysfunction and its potentiation by Ca2+.},
  author={Toshihisa Tomoda and Kazumi Takeda and Takashi Kurashige and Hideaki Enzan and Mitsuyoshi Miyahara},
  volume={14 2},
Although it has been suggested that acetylsalicylate (ASA)-induced mitochondrial dysfunction plays an important role in the pathogenesis of Reye's syndrome, administration of ASA alone does not cause this syndrome in therapeutic doses. We noted, however, that Ca2+ plays important roles in the regulation of cellular functions. ASA at concentrations of 250 microM or less, which had little effect on succinate-linked respiration, impaired Ca2+ accumulation in liver mitochondria by causing an… CONTINUE READING

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