Acetylenic acids from the aerial parts of Nanodea muscosa.

  title={Acetylenic acids from the aerial parts of Nanodea muscosa.},
  author={N El-Jaber and Ana Est{\'e}vez-Braun and Angel Guti{\'e}rrez Ravelo and O Mu{\~n}oz-Mu{\~n}oz and Abigail Rodr{\'i}guez-Afonso and Jos{\'e} Ram{\'o}n Murgu{\'i}a},
  journal={Journal of natural products},
  volume={66 5},
The aerial parts of Nanodea muscosa, collected in Chile, yielded two new acetylenic acids. Their structures were elucidated by spectroscopic analyses, including 2D NMR techniques, as (13E)-octadec-13-en-11-ynoic acid (1) and (2E)-octadec-2-en-4-ynedioic acid (2). Compound 2 constitutes the first example of a conjugated ene-yne fatty diacid isolated from a natural source. Compounds 1 and 2 did not exhibit toxicity toward a panel of DNA damage checkpoint defective yeast mutants or show affinity… CONTINUE READING

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