Acetylcholinesterase reactivators antagonize epileptiform bursting induced by paraoxon in guinea pig hippocampal slices.

Abstract

The electrophysiological actions of paraoxon, an irreversible blocker of acetylcholinesterase, and their antagonism by a series of organophosphate cholinesterase reactivators, were studied in area CA1 of the guinea pig hippocampus in vitro. To avoid indirect effects elicited by excitation of CA3 neurons, the CA2/3 regions were removed routinely before the… (More)

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