Acetylcholinesterase of human erythrocytes and neuromuscular junctions: homologies revealed by monoclonal antibodies.

@article{Fambrough1982AcetylcholinesteraseOH,
  title={Acetylcholinesterase of human erythrocytes and neuromuscular junctions: homologies revealed by monoclonal antibodies.},
  author={Douglas M. Fambrough and Andrew Geddes Engel and Terrone L. Rosenberry},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 4},
  pages={1078-82}
}
Human erythrocyte acetylcholinesterase was used to immunize mice, and hybridomas were generated by fusion of mouse spleen cells with cells of the Sp 2/0 myeloma cell line. Five independently derived hybridoma clones produced antibodies that bound to purified erythrocyte acetylcholinesterase. All of these antibodies crossreacted with human and monkey neuromuscular junctions; immunocytochemical staining patterns corresponded to the distribution of junctional acetylcholinesterase. The monoclonal… CONTINUE READING

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