Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa.

@article{Kim2004AcetylcholinesteraseIF,
  title={Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa.},
  author={Dae Keun Kim and Ki Taek Lee and N Baek and Sung-Hoon Kim and Hee Wook Park and Jong Pil Lim and Tae Yong Shin and Dong Ok Eom and Jae Heon Yang and Jae Soon Eun},
  journal={Archives of pharmacal research},
  year={2004},
  volume={27 11},
  pages={1127-31}
}
In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract of the aerial parts of Corydalis speciosa. Structures of these compounds were elucidated on the basis of spectroscopic techniques. These compounds inhibited acetylcholinesterase activity in a dose-dependent manner, and the IC50 values of compounds 1-4 were 89.0… CONTINUE READING