Acetylcholinesterase-inhibiting steroidal alkaloid from the sponge Corticium sp.

  title={Acetylcholinesterase-inhibiting steroidal alkaloid from the sponge Corticium sp.},
  author={Roosanee Langjae and S. Bussarawit and S. Yuenyongsawad and K. Ingkaninan and A. Plubrukarn},
A new stigmastane-type steroidal alkaloid, 4-acetoxy-plakinamine B (1), was isolated from the Thai sponge Corticium sp. The compound was subjected to the acetylcholinesterase inhibitory activity determination to reveal a high inhibitory activity (IC(50) 3.75+/-1.69 microM). The kinetics of enzyme inhibition showed a decrease in V(max), whereas K(m) was increased, thus suggesting an unusual mixed-competitive mode of inhibition. Compound 1 is the first steroidal alkaloid bearing a stigmastane… Expand
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