Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus.

@article{Chacn2003AcetylcholinesteraseIN,
  title={Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus.},
  author={Marcelo A Chac{\'o}n and Ariel E Reyes and Nibaldo C Inestrosa},
  journal={Journal of neurochemistry},
  year={2003},
  volume={87 1},
  pages={195-204}
}
Previous studies have demonstrated that acetylcholinesterase (AChE) promotes the assembly of amyloid-beta-peptides into neurotoxic amyloid fibrils and is toxic for chick retina neuronal cultures and neuroblastoma cells. Moreover, AChE is present in senile plaques in Alzheimer's disease (AD) brains. Here we have studied the effect of AChE on astrocytes and hippocampal neurons in vivo. Morphological as well as behavioral disturbances were analyzed after intrahippocampal injection of AChE. Rats… CONTINUE READING

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