Acetylcholinesterase imaging: its use in therapy evaluation and drug design.

  title={Acetylcholinesterase imaging: its use in therapy evaluation and drug design.},
  author={Hitoshi Shinotoh and Kiyoshi Fukushi and Shin-ichiro Nagatsuka and Toshiaki Irie},
  journal={Current pharmaceutical design},
  volume={10 13},
Several cholinesterase (ChE) inhibitors have been labeled with carbon-11 for visualizing binding sites on acetylcholinesterase (AChE) by positron emission tomography (PET). Following intravenous injection of 1,2,3,4-tetrahydro-9-[(11)C]methylaminoacridine or [(11)C]donepezil, however, the radioactivity distribution does not reflect the regional distribution of AChE in the brain of animals, probably because these compounds have high non-specific binding and/or other specific binding sites in… CONTINUE READING
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