Acetylcholinesterase has a non-cholinergic neuromodulatory action in the guinea-pig substantia nigra

@article{Last1987AcetylcholinesteraseHA,
  title={Acetylcholinesterase has a non-cholinergic neuromodulatory action in the guinea-pig substantia nigra},
  author={A. T. J. Last and Susan Adele Greenfield},
  journal={Experimental Brain Research},
  year={1987},
  volume={67},
  pages={445-448}
}
SummaryAcetylcholinesterase is released within the substantia nigra from the soma/dendrites of nigrostriatal neurons. Previous work suggests that this phenomenon is independent of cholinergic systems, but rather serves to modulate the sensitivity of dopamine-containing nigrostriatal cells to synaptic events. This hypothesis was tested directly in the anaesthetized guinea-pig. Micro-infusion of acetylcholinesterase into the substantia nigra led to an increase in spontaneous firing of… CONTINUE READING
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