Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort.

@article{Adsersen2007AcetylcholinesteraseAB,
  title={Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort.},
  author={Anne Adsersen and Anne Louise Kj\olbye and Ole M. Dall and Anna K J{\"a}ger},
  journal={Journal of ethnopharmacology},
  year={2007},
  volume={113 1},
  pages={179-82}
}
In the course of screening plants used in Danish folk medicine as memory enhancers, a crude methanolic extract of tubers from Corydalis cava showed significant acetylcholinesterase inhibitory activity in a dose-dependent manner. Activity guided fractionation of the methanolic extract resulted in the isolation of three alkaloids, bulbocapnine (1), corydaline (2) and corydine (3) as active constituents. Bulbocapnine inhibited acetylcholinesterase as well as butyrylcholinesterase in a dose… CONTINUE READING