Acetylcholinesterase activation and enhanced lipid peroxidation after long-term exposure to low levels of aluminum on different mouse brain regions.

@article{Kaizer2005AcetylcholinesteraseAA,
  title={Acetylcholinesterase activation and enhanced lipid peroxidation after long-term exposure to low levels of aluminum on different mouse brain regions.},
  author={Rosilene Rodrigues Kaizer and Ma{\'i}sa de Carvalho Corr{\^e}a and Roselia M Spanevello and Vera M Morsch and C{\'i}ntia M Mazzanti and Jamile Fabbrin Gonçalves and Maria Rosa Schetinger},
  journal={Journal of inorganic biochemistry},
  year={2005},
  volume={99 9},
  pages={1865-70}
}
Aluminum (Al), oxidative stress and impaired cholinergic functions have all been related to Alzheimer's disease (AD). The present study evaluates the effect of aluminum on acetylcholinesterase (AChE) and lipid peroxidation in the mouse brain. Mice were loaded by gavage with Al 0.1 mmol/kg/day 5 days per week during 12 weeks. The mice were divided into four groups: (1) control; (2) 10 mg/mL of citrate solution; (3) 0.1 mmol/kg of Al solution; (4) 0.1 mmol/kg of Al plus 10 mg/mL of citrate… CONTINUE READING