Corpus ID: 86201471

Acetylcholinesterase Inhibitory Activity of Oxazole Derivatives

  title={Acetylcholinesterase Inhibitory Activity of Oxazole Derivatives},
  author={C. Dias and M. Brito and A. Eleut{\'e}rio and J. Marco and D. Brites and M. Carreiras},
Alzheimer’s disease (AD) is the most common form of dementia among persons over 65 years of age. It is a brain neurodegenerative disorder characterised by loss of memory and cognition. Current treatment is symptomatic, with the major therapeutic strategy based on the “cholinergic hypothesis”, specifically acetylcholinesterase (AChE) inhibition. Tacrine (THA) was the first and one of the few drugs approved in the last decade for the treatment of AD. However, due to the important adverse effects… Expand