Acetylcholinesterase: from 3D structure to function.

  title={Acetylcholinesterase: from 3D structure to function.},
  author={Hay Dvir and Israel Silman and Michal Harel and Terrone L. Rosenberry and Joel L. Sussman},
  journal={Chemico-biological interactions},
  volume={187 1-3},
By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, functioning at a rate approaching that of a diffusion-controlled reaction. The powerful toxicity of organophosphate poisons is attributed primarily to their potent inhibition of acetylcholinesterase. Acetylcholinesterase inhibitors are utilized in the treatment of various neurological disorders, and are the principal… CONTINUE READING


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