Acetylcholinesterase: from 3D structure to function.

  title={Acetylcholinesterase: from 3D structure to function.},
  author={Hay Dvir and Israel Silman and Michal Harel and Terrone L. Rosenberry and Joel L. Sussman},
  journal={Chemico-biological interactions},
  volume={187 1-3},
By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, functioning at a rate approaching that of a diffusion-controlled reaction. The powerful toxicity of organophosphate poisons is attributed primarily to their potent inhibition of… CONTINUE READING