Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.

@article{Taylor2007AcetylcholinesteraseCA,
  title={Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.},
  author={Palmer Taylor and Zrinka Kovarik and Elsa Reiner and Zoran Radic},
  journal={Toxicology},
  year={2007},
  volume={233 1-3},
  pages={70-8}
}
Applications of recombinant DNA technology, chemical synthesis on biological templates and fluorescence detection of organophosphorylation provide unexplored avenues for development of antidotes and approaches for remote detection of organophosphate nerve agents and pesticides. We discuss here how acetylcholinesterase (AChE), through appropriate mutations, becomes more susceptible to oxime reactivation. Since the reaction between organophosphate and the mutated enzyme remains rapid… CONTINUE READING

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