Acetylcholinesterase, butyrylcholinesterase and paraoxonase 1 activities in rats treated with cannabis, tramadol or both.

@article{AbdelSalam2016AcetylcholinesteraseBA,
  title={Acetylcholinesterase, butyrylcholinesterase and paraoxonase 1 activities in rats treated with cannabis, tramadol or both.},
  author={Omar M. E. Abdel-Salam and Eman Refaat Youness and Yasser A Khadrawy and Amany Ameen Sleem},
  journal={Asian Pacific journal of tropical medicine},
  year={2016},
  volume={9 11},
  pages={1089-1094}
}
OBJECTIVE To investigate the effect of Cannabis sativa resin and/or tramadol, two commonly drugs of abuse on acetylcholinesterase and butyrylcholinesterase activities as a possible cholinergic biomarkers of neurotoxicity induced by these agents. METHODS Rats were treated with cannabis resin (5, 10 or 20 mg/kg) (equivalent to the active constituent Δ9-tetrahydrocannabinol), tramadol (5, 10 and 20 mg/kg) or tramadol (10 mg/kg) combined with cannabis resin (5, 10 and 20 mg/kg) subcutaneously… CONTINUE READING